منابع مشابه
Discovering the first tyrosine kinase.
In the middle of the 20th century, animal tumor viruses were heralded as possible models for understanding human cancer. By the mid-1970s, the molecular basis by which tumor viruses transform cells into a malignant state was beginning to emerge as the first viral genomic sequences were reported and the proteins encoded by their transforming genes were identified and characterized. This was a ti...
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Background: When Staphylococcus aureus is grown in the presence of high concentration of external glucose, this sugar is phosphorylated by glucokinase (glkA) to form glucose-6-phosphate. This product subsequently enters into anabolic phase, which favors biofilm formation. The presence of ROK (repressor protein, open reading frame, sugar kinase) motif, phosphate-1 and -2 sites, and tyrosine kina...
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Correspondence to Sakari Kauppinen: [email protected] Abbreviations used in this paper: HCV, hepatitis C virus; LNA, locked nucleic acid; miRNA, microRNA; PS, phosphorothioate ; UTR, untranslated region. The discovery of microRNAs: From worm genetics to human disease The first miRNA gene, lin-4, was discovered in Caenorhabditis elegans by Victor Ambros and Gary Ruvkun in 1993 (Fig. 1), and shown to...
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MicroRNAs (miRNAs) are important post-transcriptional regulators of nearly every biological process in the cell and play key roles in the pathogenesis of human disease. As a result, there are many drug discovery programs that focus on developing miRNA-based therapeutics. The most advanced of these programs targets the liver-expressed miRNA-122 using the locked nucleic acid (LNA)-modified antise...
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We analyze the potential of the first LHC physics run, assuming 1 fb−1 at √ s = 7 TeV, to discover Supersymmetry (SUSY). The results are based on SUSY parameter fits following a frequentist approach. They include the experimental constraints from electroweak precision data, (g − 2)μ, B physics and cosmological data. The two SUSY models under consideration are the constrained MSSM (CMSSM) with u...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2015
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1508223112